Resveratrol is associated with a plethora of physiological effects in humans, including modulation of cerebral blood flow, despite apparently poor bioavailability. This study investigated whether the physiological effects of resveratrol could be affected when co-supplemented with piperine, an alkaloid which may be able to enhance the bioavailability of resveratrol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
DOUBLE
Enrollment
23
All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.
All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.
Brain performance and nutrition research centre, Northumbria university
Newcastle upon Tyne, Tyne and Wear, United Kingdom
Modulation of levels of total haemoglobin
Time frame: 80 minutes following treatment administration
Modulation of levels of deoxygenated haemoglobin
Time frame: 80 minutes following treatment administration
Modulation of levels of oxygenated haemoglobin
Time frame: 80 minutes following treatment administration
Number of participants displaying significant modulation of cognitive performance
Cognitive performance was assessed at baseline and then again 40 minutes post-treatment to assess if any changes had taken place.
Time frame: 40-80 minutes post dose
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