Clinical Study of a Conventional and Flexible Extended Oral Contraceptive of EE/DRSP With or Without Metafolin in Latin America

Inclusion Criteria: * Healthy female volunteers between 18 and 35 years of age (smokers up to 30 years, inclusive) who request contraceptive protection Exclusion Criteria: * Pregnancy or lactation (less than 3 months since delivery, abortion, or lactation before start of treatment) * Body mass index (BMI) \>/= 30.0 kg/m2 * Presence or a history of venous or arterial thrombotic/thromboembolic events * Repeated measurements of systolic blood pressure \> 140 mmHg and/or diastolic blood pressure \> 90 mmHg * Presence or history of liver tumors (benign or malignant), severe hepatic disease, jaundice and/or pruritus related to cholestasis, cholestatic jaundice associated with pregnancy or previous combined oral contraceptive (COC) use * Uncontrolled diabetes mellitus and/or diabetes mellitus with vascular involvement * Severe dyslipoproteinemia * Malignant or premalignant disease * Uncontrolled thyroid disorder * Chronic inflammatory bowel disease