Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis

Oregon Health and Science University966 enrolled

Overview

This research study will be completed by enrolling a prospective, observational cohort study to evaluate medical versus surgical treatment outcomes for chronic sinus disease. This investigation will compare quality of life outcomes between each treatment type, as well as measure cellular and molecular markers of inflammation in the sinus mucosa, to create models that predict improvement in quality of life following treatment.

Study Type

OBSERVATIONAL

Enrollment

966

Conditions

Chronic Rhinosinusitis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult (\>= 18 years) * Chronic rhinosinusitis as defined by the 2007 multi-disciplinary adult sinusitis guidelines * Able to complete all surveys/questionnaires in English * Persistent symptoms following initial medical management * Received at least 1 course of broad spectrum antibiotics or culture directed antibiotics for at least a total of 14 days * Received at least a 3 week trial of topical steroid sprays OR at least a 5 day trial of systemic corticosteroid therapy. * Counseled for subsequent treatment options including either medical management or endoscopic sinus surgery Exclusion Criteria: * Children (\<18 years) * Unable to complete all surveys/questionnaires at baseline

Locations (1)

Oregon Health & Science University

Portland, Oregon, United States

Outcomes

Primary Outcomes

Disease-specific quality of life

Time frame: 18 months post-treatment

Secondary Outcomes

General health-related quality-of-life

Time frame: 18 months post-treatment

Olfaction

Time frame: 18 months post-treatment

Data from ClinicalTrials.gov

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