The purpose of this study is to evaluate the benefit of the optimal pacing configuration, including the possibility of biventricular or left ventricular pacing, in hypertrophic obstructive cardiomyopathy patients.
In this study, subjects will be randomized to Cardiac Resynchronization Therapy-Defibrillation (CRT-D) or Cardiac Resynchronization Therapy-Pacing (CRT-P) vs Pacing Therapy AAI. Randomization will be stratified by indication. Optimal pharmacological therapy in both treatment arms. Length of follow-up for each subject will be 2y, since all subjects will be followed to a common study termination date.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
All patients will be pacing during two years
No Pacing during the first year. In the second year all patients will be pacing
Hospital Clinic i Provincial de Barcelona
Barcelona, Spain
RECRUITINGChange from Baseline in Left ventricular mass and resting left ventricular outflow tract gradient (mmHg).
Change from Baseline in Left ventricular mass and resting left ventricular outflow tract gradient (mmHg)
Time frame: 1 and 2 years
Change from Baseline in Clinical evaluation of NYHA,QoL,6MWT,interventricular septum thickness,posterior wall thickness,provoked left ventricular outflow tract gradient,mitral regurgitation grade.
Change from Baseline in Clinical evaluation (New York Heart Association(NYHA), Quality of life Questionnaire (QoL), 6 Minutes Walk Test (6MWT)), interventricular septum thickness, posterior wall thickness, provoked left ventricular outflow tract gradient, mitral regurgitation grade.
Time frame: 1 and 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.