GLP-1: Acute Effects on Kidney Function in Healthy Men

Jeppe Skov12 enrolled

Overview

The purpose of this study is to investigate how Glucagon-Like Peptide 1 (GLP-1) affects kidney function in healthy young men. The hypothesis is that GLP-1 induces a positive effect on kidney hemodynamics.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Kidney Functional

Interventions

Human GLP-1 (7-36) amideBIOLOGICAL

2 hour IV infusion, 1,5pmol/min/kg.

Isotone NaClBIOLOGICAL

2 hours IV infusion.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy young men Exclusion Criteria: * Any chronic diseases

Locations (1)

Klinisk Institut, Afd. MEA, Aarhus Sygehus, NBG

Aarhus C, Denmark

Outcomes

Primary Outcomes

Glomerular Filtration Rate

Time frame: Every 20 minutes for 6 hours

Data from ClinicalTrials.gov

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