IGEV Followed by Autologous Transplantation for Refractory or Relapsed Hodgkin Lymphoma

Inclusion Criteria: * Age range: 18-65 years old * Histological confirmed refractory or relapsed Hodgkin lymphoma * With at least one site of measurable disease according to IWC criteria * ECOG performance status 0-1 * Life expectancy of more than 3 months * Bone marrow function: ANC≧1.5×109/L, PLT≧100×109/L, Hb≧80g/L * Liver function: total bilirubin, ALT and AST \<1.5×UNL * Renal function: Cr\<1.5×UNL, CCR≧45ml/min * No contraindication for transplantation Exclusion Criteria: * No prior chemotherapy * With more than 2 lines of prior chemotherapy exposure * Evidence of CNS and bone marrow involvement * History of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix * Pregnant or lactating women * Significant active infection