Effects of Pregabalin on Pain After Total Knee Arthroplasty

Inclusion Criteria: * Patients with osteoarthritis scheduled for primary tricompartmental total knee arthroplasty with a participating surgeon * Age 18 to 80 years old * Planned use of regional anesthesia * Ability to follow study protocol * English speaking (primary outcome obtained via telephone call and secondary outcomes include questionnaires validated in English only) * Patients planning on being discharged home or to a rehabilitation center that has agreed to participate Exclusion Criteria: * Patients younger than 18 years old and older than 80 * Patients intending to receive general anesthesia * Allergy or intolerance to one of the study medications * Patients with an ASA of IV * Patients with hepatic (liver) failure * Patients with chronic renal (kidney) failure (Defined as estimated creatinine clearance \< 30 mL/min, based on recommendation that total daily pregabalin dose be reduced to 150 mg with Clcr \< 30 mL/min, CLcr=\[(140-age (years)\] x weight (kg)x0.85 (for female patients)/\[72xserum creatinine (mg/dL)\]) * Patients with difficult to manage diabetes mellitus, including insulin-dependence * Chronic gabapentin/pregabalin use (regular use for longer than 3 months) * Chronic opioid use (taking opioids for longer than 3 months) * Patients with major prior ipsilateral open knee surgery. * Chronic neurontin/lyrica use