A Study to Determine the Pharmacodynamics of LX4211 Relative to Meals in Healthy Subjects

Inclusion Criteria: * Adults ≥18 and ≤55 years of age * Vital signs at Screening in the following ranges: systolic blood pressure, 90-140 mm Hg; diastolic blood pressure, 50-90 mm Hg; heart rate, 50-100 bpm * Body mass index (BMI) ≥18 and ≤35 kg/sq m * Able to provide written informed consent Exclusion Criteria: * Use of any medication (prescription, over-the-counter, herbal tea, or supplements) within 5 days of dosing * Use of any investigational agent or study treatment within 30 days of Day 1 * Use of any protein or antibody-based therapeutic agents within 3 months of Screening * Prior exposure to any SGLT inhibitor * Use of cigarettes or any tobacco products within 6 weeks prior to Screening and while participating in the study * History of bariatric surgery or any other gastrointestinal surgery that may induce malabsorption * History of any major surgery within 6 months of Screening * History of any hypersensitivity to the inactive components of LX4211 * History of renal disease or significantly abnormal kidney function tests * History of hepatic disease or significantly abnormal liver function tests * History of any active infection within 30 days of Day 1 * History of alcohol or substance abuse within 2 years prior to Day 1 * Positive urine glucose at Screening * Positive pregnancy test at Screening * Inability or difficulty swallowing whole tablets or capsules * Unable or unwilling to communicate or cooperate with the Investigator.