Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study)

Inclusion Criteria: * Patient greater than or equal to 35 years of age * High resolution CT scan indicates unilateral or bilateral emphysema * High resolution CT scan indicates homogeneous or heterogeneous emphysema * Patient has post-bronchodilator FEV1 less than or equal to 45% predicted * Total Lung Capacity greater than 100% predicted * Patient has marked dyspnea scoring greater than or equal to 2 on mMRC scale of 0-4 * Patient has stopped smoking for a minimum of 8 weeks prior to entering the study * Patient (and legal guardian if applicable) read, understood and signed the Informed Consent form Exclusion Criteria: * Patient has a change in FEV1 greater than 20% post-bronchodilator * Patients DLCO less than 20% predicted * Patient has a history of recurrent clinically significant respiratory infection * Patient has uncontrolled pulmonary hypertension defined by right ventricular pressure greater than 50mm Hg and/or evidenced by echocardiogram * Patient has an inability to walk greater than 140 meters (150 yards) in 6 minutes * Patient has evidence of other disease that may compromise survival such as lung cancer, renal failure, etc * Patient is pregnant or lactating * Patient has an inability to tolerate bronchoscopy under heavy sedation or anesthesia * Patient has clinically significant bronchiectasis * Patient has giant bullae greater than 1/3 lung volume * Patient has had previous LVR surgery, lung transplant or lobectomy * Patient has been involved in other pulmonary drug studies with 30 days prior to this study * Patient is taking greater than 20 mg prednisone (or similar steroid) daily * Patient is on Plavix or has not been weaned off prior to procedure * Patient has other disease that would interfere with completion of study, follow up assessments or that would adversely affect outcomes