Efficacy of Letrozole and CC Alone in an IUI Program in Cases With Surgically Treated Minimal to Mild Endometriosis

Mansoura University136 enrolled

Overview

To evaluate pregnancy rates with letrozole and CC alone in an IUI program for women with recently surgically treated minimal to mild endometriosis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

136

Conditions

Endometriosis

Interventions

Letrozole/IUIDRUG

Patients received 5 mg letrozole daily for 5 days. A single insemination was performed 32-36 hours after hCG (10,000 IU, IM). Patients underwent up to four cycles of treatment.

CC/IUIDRUG

Patients received 100 mg lCC daily for 5 days. A single insemination was performed 32-36 hours after hCG (10,000 IU, IM). Patients underwent up to four cycles of treatment.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 36 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient with minimal-mild endometriosis recently treated by laparoscopy with a waiting period of 6 to 12 months following the procedure * No other infertility factors. * Normal serum basal hormone levels as well as documented ovulation Exclusion Criteria: * Moderate or severe endometriosis * Dense adnexal and/or ovarian adhesions due to pelvic inflammatory disease or previous pelvic surgery * Age more than 36 years, BMI more than 30 kg/m2 * women with a previous pregnancy

Locations (1)

Mansoura University Hospitals,OB/GYN department

Al Mansurah, Dakahlia Governorate, Egypt

Outcomes

Primary Outcomes

Clinical pregnancy rate per cycle

Time frame: 6-7 weeks gestation

Secondary Outcomes

Miscarriage rate.

Time frame: Up to 20 weeks gestation

Data from ClinicalTrials.gov

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