Mechanism of Action of Vichy Catalan Water

National Research Council, Spain21 enrolled

Overview

Water consumption is essential to maintain hydration and good health. Sodium-bicarbonated mineral waters are reported to have beneficial digestive and hypocholesterolemic properties. The aim of this study was to investigate the effects of the consumption of a sodium-bicarbonated mineral water (BW) with or without a meal, compared to a low mineral content water as a control water (CW), on postprandial serum triacylglycerols (TAG), cholecystokinin (CCK), and gallbladder volume.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Cardiovascular Diseases

Interventions

Bicarbonated mineral waterDIETARY_SUPPLEMENT

Volunteers fasted overnight consumed: 0.5 L of the bicarbonated mineral water without meal or, 0.5 L of the bicarbonated mineral water with meal

Mineral water low in mineral content (control)DIETARY_SUPPLEMENT

Volunteers fasted overnight consumed: 0.5 L of the control water without meal or, 0.5 L of the control water with meal

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult (\>18 and \<40 years) * BMI \>18 and \<30 kg/m2 Exclusion Criteria: * Age \<18 and \> 40 years * TAG \> 250 mg/dL (2.82 mmol/L) * Being a usual consumer of carbonic mineral water * Obesity * Diabetes * Hypertension or digestive, liver and renal disease * Biliary obstruction * Eating disorders * Being under medication that could affect lipid metabolism * Consumption of functional foods that could affect lipid metabolism (food containing n-3 fatty acids or phytosterols)

Locations (1)

Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CISC)

Madrid, Madrid, Spain

Outcomes

Primary Outcomes

Serum triacylglycerols

Time frame: Baseline

Serum triacylglycerols

Time frame: Postprandial 30 minutes

Serum triacylglycerols

Time frame: Postprandial 60 minutes

Serum triacylglycerols

Time frame: Postprandial 120 minutes

Secondary Outcomes

Serum glucose

Time frame: Baseline

Serum glucose

Time frame: Postprandial 30 minutes

Serum glucose

Time frame: Postprandial time 60 minutes

Serum glucose

Time frame: Postprandial time 120 minutes

Serum insulin

Time frame: Baseline

Serum insulin

Time frame: Postprandial 30 minutes

Serum insulin

Time frame: Postprandial 60 minutes

Serum insulin

Time frame: Postprandial 120 minutes

Cholecystokinin

Time frame: Baseline

Data from ClinicalTrials.gov

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