A Study to Assess Selected Biomarkers in Subjects Requiring Daily Inhaled Corticosteroids for Persistent Asthma

Inclusion Criteria: * Age 18 through 75 at the time of screening * Written informed consent and any locally required authorization obtained from the subject prior to performing any protocol-related procedures, including screening evaluations * History of physician-diagnosed asthma for at least 12 months prior to screening * Stable Medium- to high-dose ICS divided twice daily as outlined by the NHLBI Asthma Guidelines, 2007 Exclusion Criteria: * Any medical condition that, in the opinion of the investigator or medical monitor, would interfere with interpretation of subject safety or study results * Concurrent enrollment in another clinical study * Use of immunosuppressive medication within 3 months prior to screening * Acute upper or lower respiratory infections requiring antibiotics or antiviral medications with in 30 days prior to screening or during screning period. * Receipt of immunoglobulin or blood products within 30 days prior to screening or during the screening period * Receipt of any investigational non-biological drug therapy within 30 days or 5 half-lives prior to screening whichever is longer; or receipt of any marketed or investigational biologic within 6 months or 5 half-lives prior to screening whichever is longer * Pregnant, lactating, or breastfeeding woman * Diagnosis of lung disease other than persistent asthma * History of smoking ≥10 pack years or any smoking within 12 months prior to screening * History of active, infectious hepatitis A, B, C or human immunodeficiency virus (HIV)