A Study to Investigate the Safety and Effect of Food on the Pharmacokinetics of YM178 in Healthy Volunteers

Inclusion Criteria: * A normal or clinically non-significant 12 lead ECG as well as normal or clinically non-significant laboratory test results at the time of Screening * Body weigh at least 50 kg in male and 45 kg in female and body mass index (BMI) between 18.5 and 26.9 kg/m2 * All women of child bearing potential are required to use adequate contraception consisting of two forms of birth control Exclusion Criteria: * Hypersensitivity to YM178 or other beta-3 agonists or any of the constituents of the formulation used * Liver function test values above the upper limit of normal * A history or presence of psychiatric illness, serious active or recurrent infection * A previous history of cancer other than basal cell carcinoma or Stage 1 squamous cell carcinoma that has not been in remission for at least 5 years prior to the study * Donated or lost ≥ 500 mL blood within 3 months or donated plasma within 2 weeks prior to the study * Receiving or being anticipated to receive a prescription drug or OTC medications within 14 days prior to the study * Consuming alcohol, xanthine derivative-containing food/beverages (tea, chocolate), grapefruit juice, grapefruit-containing products or Seville oranges (e.g., bitter marmalade) within 48 hours before the study * A history of substance abuse, drug addiction, or alcoholism within past 2 years prior to the study * currently participating in another clinical trial or taking or has been taking an investigational drug at least 60 days