The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of AZD5213 in healthy young and elderly Japanese subjects
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
48
Four increasing doses for young and two increasing doses for elderly subjects. Subject will receive single dose of AZD5213 oral solution (Day 1) and then start the once daily repeated doses from Day 3 to 12 for 10 days
Placebo solution, single dose (Day 1) and repeated dose from Day 3 to 12 for 10 days
Research Centre
Fukuoka, Japan
To assess the safety and tolerability of AZD5213 by assessment of adverse event, vital signs, laboratory parameters and electrocardiograms (ECGs).
Time frame: Range of Days 1-12
To assess the PK of AZD5213 after a single and multiple doses by assessment of Cmax.
Time frame: Range of Days 1-12
To assess the PK of AZD5213 after a single and multiple doses by assessment of fe.
Time frame: Range of Days 1-12
To assess the PK of AZD5213 after a single and multiple doses by assessment of CLR.
Time frame: Range of Days 1-12
To assess the PK of AZD5213 after a single and multiple doses by assessment of CL/F.
Time frame: Range of Days 1-12
To assess the PK of AZD5213 after a single and multiple doses by assessment of t1/2.
Time frame: Range of Days 1-12
To assess the PK of AZD5213 after a single and multiple doses by assessment of tmax.
Time frame: Range of Days 1-12
To assess the PK of AZD5213 after a single and multiple doses by assessment of AUC.
Time frame: Range of Days 1-12
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