Main Branch Versus Side Branch Ostial Lesion

Seoul National University Hospital77 enrolled

Overview

The investigators studied the relations between coronary angiography (CAG), intravascular ultrasound (IVUS) and fractional flow reserve (FFR) in coronary ostial lesions.

Angiographic evaluation for ostial lesions is reported to be inaccurate in the assessment of the functional and clinical significance of a lesion. The investigators studied the relations between coronary angiography (CAG), intravascular ultrasound (IVUS) and fractional flow reserve (FFR) in coronary ostial lesions.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coronary Artery Stenosis

Interventions

Fractional flow reserveDEVICE

Fractional flow reserve measured by pressure wire

IVUSDEVICE

intravascular ultrasound :IVUS was performed in a standard fashion using an automated motorized pullback system (0.5mm/s) with commercially available imaging catheter

Eligibility

Sex: ALLMin age: 21 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 21-85 * Presence of at least one obstructive coronary artery stenosis at coronary ostium as defined by: * Previous catheterization with any coronary ostium lesion 50% or greater * Ability and Willingness to provide informed consent * Ability and Willingness to perform required follow up procedures Exclusion Criteria: * History of coronary artery bypass graft surgery * left main coronary ostial lesion * significant stenosis at proximal or distal part of coronary ostium lesion * ostial lesion related to infarcton * Creatinine\>1.6 mg/dL or GFR\<30 pre-procedure per institutional standards * Ejection fraction lower than 40% * Known Pregnancy * Arrhythmia * Contrast agent allergy that cannot be adequately premedicated * Patient not a candidate for IVUS and FFR * Inability or unwillingness to provide informed consent * Inability or unwillingness to perform required follow up procedures

Outcomes

Primary Outcomes

lumen area

lumen area at ostial lesion

Time frame: 1 day

Secondary Outcomes

angiographic stenosis, % plaque area

angiographic and intravascular ultrasound parameters at ostial lesions of each major branch and side branch.

Time frame: 1 day

Data from ClinicalTrials.gov

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