This study is a clinical comparison of the biocompatibility of several multipurpose solutions, Renu Fresh, Optifree Replenish, and ClearCare, and saline as a control solution among adapted hydrogel contact lens wearers wearing Avaira (enfilcon A) contact lenses at one research site.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
32
B\&L Renu Fresh Multipurpose Solution
Optifree Replenish Multipurpose Solution
Ciba ClearCare Multipurpose Solution
Erdey/Searcy Eye Group
Columbus, Ohio, United States
Corneal Staining Severity
Severity of staining was recorded for each region using a scale of 0-none to 4-patch \>/=1mm. Analysis of staining was performed by averaging the scores from the five regions for each eye, then identifying the subject's worse eye at each visit. Mean total severity was calcuated from all identified eyes for each visit.
Time frame: Baseline, 2 Hour Period, 4 Hour Period
Corneal Staining Area
Analysis of staining area was performed by averaging the values from the five regions for each eye and then identifying the subject's worse eye at each visit. Mean total area was calculated from all identified eyes for each visit.
Time frame: Baseline, 2 Hour Period, 4 Hour Period
Subjective Comfort
Subjective comfort ratings 0-100 (0=causes pain, 100=excellent comfort)
Time frame: Visit 1: Baseline; Visit 2: 2 hours, Visit 3: 4 hours
Subjective Dryness
Subjective dryness ratings 0-100 (0=extremely dry, 100=extremely moist)
Time frame: Visit 1: Baseline; Visit 2: 2 hours, Visit 3: 4 hours
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Saline Solution