Causes and Outcomes of Community Acquired Pneumonia

Oxford University Clinical Research Unit, Vietnam300 enrolled

Overview

This is a descriptive clinical research aiming: * To describe the clinical spectrum and clinical characteristics of community acquired pneumonia (CAP) in patients admitted to hospital * To identify the etiology of CAP and the antibiotic sensitivity of the isolated organisms * To identify the risk factors that influence the severity of CAP

In Vietnam, the range and relative contribution of organisms causing CAP remain unclear, largely because diagnostic tools are limited and clinical research uncommon. An improved understanding of the risk factors, etiology and clinical outcomes of CAP in Vietnam would contribute to improved approaches to patient diagnosis and clinical management. This will be achieved by following the clinical and laboratory progress and treatment outcomes of in-patients diagnosed with CAP from admission to discharge. Comparative analyses will be between subgroups including survivor and non-survivor, severe CAP and non-severe CAP, known etiology and unknown etiology, SIRS, sepsis, severe sepsis and shock septic.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Community Acquired Pneumonia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients \> or = 18 years of age * Patient meets the criteria of pneumonia (below), established within 36h of hospitalization * Patient is not hospitalized or residing in a long-term-care facility within 14 days before the onset of symptoms * Patient has not been at a referral hospital for \>2 days before admission to the study hospital * Informed consent to participate in the study is provided Exclusion Criteria: * Severe immunosuppression as judged by the enrolling physician (e.g. HIV, leukemia, lymphoma, chemotherapy for solid tumors, long-term corticosteroid use or other immunosuppressive drugs) * Known active tuberculosis or current treatment for tuberculosis

Locations (2)

National Hospital of Tropical Diseases

Hanoi, Hanoi, Vietnam

Nguyen Tri Phuong Hospital

Ho Chi Minh City, Vietnam

Outcomes

Primary Outcomes

Proportion of patients who are stable at Day 3, 7 and 14

• Criteria for clinical stability * Temperature \< or = 37.8oC * Heart rate \< or = 100 beats/min * Respiratory rate \< or = 24 breaths/min * Systolic blood pressure \> or = 90 mm Hg * Arterial oxygen saturation \> or = 90% or pO2 \> or = 60 mm Hg on room air * Ability to maintain oral intake * Normal mental status

Time frame: up to 14 days

Secondary Outcomes

Day 14 mortality

Proportion of patients who die at Day 14

Time frame: 14 days

Length of stay (days)

Length of stay from admission to discharge in days

Time frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Need for mechanical ventilation

Time frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Length of ventilation time

Time frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Data from ClinicalTrials.gov

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