Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.

Inclusion Criteria: * Provision of informed consent prior to any study specific procedures * Males or females aged 18 to 55 years (inclusive) * Minimum weight of 50 kg and a body mass index (BMI) of 18 to 35 kg/m2 (inclusive) * Female subjects must have a negative pregnancy test at screening and admission of each treatment period, must not be lactating, and must be of non-childbearing potential Exclusion Criteria: * History or presence of gastrointestinal, hepatic or renal disease (except for cholecystectomy) * Any clinically significant illness, medical or surgical procedure, or trauma within 4 weeks before Period 1 Day 1 * Subjects who smoke more than 5 cigarettes or the equivalent in tobacco per day * Absolute neutrophil count of less than 2500/mm3 or 2.5 x 109/L * Any previous treatment with fostamatinib