Metformin and Sitagliptin in Women With Previous Gestational Diabetes

Inclusion Criteria: * Female subjects aged ≥18 and ≤45 years * Caucasian race * History of previous gestational diabetes (in the screening) during pregnancy. * Female of childbearing potential must use effective contraceptive measures for at last 1 month prior to entry into the study and should continue to use the some contraceptive method during the overall study period * Written informed consent obtained Exclusion Criteria: * Patients diagnosed with type 1 insulin dependent diabetes * Diagnosis of diabetes in the 75g OGTT performed at entry * BMI ≤18 or ≥50 Kg/m2 * Chronic impaired renal function * Impaired liver function as shown by transaminase levels ≥ twice above the upper normal range * History of hypersensitivity to metformin * Pregnant or breast-feeding women, or women planning to become pregnant during the study * Failure to use adequate contraception (Women of current reproductive only) * Mental condition rending the subject unable to understand the nature, scope and possible consequences of the study * Any clinically significant major organ system disease * Patients with underlying concomitant medication requiring a long-term use of drugs potentially acting on glucose metabolism (e.g. corticosteroids, diuretics, beta-adrenergic drugs or others) * Treatment or likelihood of requiring treatment during the study period with drugs not permitted by the clinical study protocol * History of drug or alcohol abuse within the last 2 years or current addiction to substances of abuse * Any disease or condition that in the opinion of the investigator may interfere with the completion of the study * Subjects unlikely to comply with the protocol