Facilitation Through Aggrastat By drOpping or Shortening Infusion Line in Patients With ST-segment Elevation Myocardial Infarction Compared to or on Top of PRasugrel Loading dOse

Inclusion Criteria: * Chest pain for \>30 min with an electrocardiographic ST-segment elevation more than 1 mm in two or more contiguous electrocardiogram (ECG) leads, or with a new left bundle-branch block, and admission either within 12 h of symptom onset or between 12 and 24 h after onset with evidence of continuing ischemia Exclusion Criteria: * Administration of fibrinolytic or any GP IIbIIIa inhibitors for the treatment of current AMI or within 1 month before history of bleeding diathesis * Known sensitivity to abciximab, to any component of the product or to murine monoclonal antibodies * Major surgery or trauma within 30 days * Active bleeding * Previous stroke in the last six months * Oral anticoagulant therapy * Pre-existing thrombocytopenia * Vasculitis * Hypertensive retinopathy * Severe hepatic failure * Severe renal failure requiring haemodialysis * Documented allergy/intolerance or contraindication to clopidogrel or inability to assume clopidogrel on a consecutive daily basis for a minimum of 30 days, or to heparin or aspirin * Uncontrolled hypertension (systolic or diastolic arterial pressure \>180 mmHg or 120, respectively, despite medical therapy) * Limited life expectancy, e.g. neoplasms, others * Inability to obtain informed consent