Dose-Finding of Retinoid 9cUAB30 in Healthy Volunteers

Inclusion Criteria: * ECOG performance status =\< 1 (Karnofsky \>= 70%) * WBC \>= 3000/mm\^3 * Platelets \>= 100,000mm\^3 * Bilirubin =\< upper limit of institutional normal * AST =\< upper limit of institutional normal * Creatinine within institutional normal limits * Sodium =\< upper limit of institutional normal * Potassium =\< upper limit of institutional normal * Chloride =\< upper limit of institutional normal * Bicarbonate =\< upper limit of institutional normal * Fasting triglycerides =\<1.5 x ULN * Fasting cholesterol =\< 1.5 x ULN * Participants must agree to discontinue all vitamin supplements while taking study medication and for thirty days past the last dose of study medication * The effects of 9cUAB30 on the developing human fetus are unknown; for this reason, women must agree to use TWO effective forms of birth control for the duration of study participation and for 30 days following the last dose of study medication * The following persons are not considered to be able to father or bear children and therefore are eligible to participate without the use of concurrent birth control: * Female with bilateral oophorectomy and/or hysterectomy * Female with fallopian tubes cut, tied, or sealed * Female with sterilization implant (e.g. Adiana, Essure) placed \> 3 months prior to randomization * Female post-menopausal (\> 1 year since last menses) * Male with vasectomy \> 3 months prior to randomization * One of the following methods of birth control must be used by women of childbearing potential: * Combined oral contraceptive pill in continuous use for \> 30 days prior to study entry * Vaginal ring (e.g. NuvaRing) in continuous use for \> 30 days prior to study entry * Skin patch (e.g. Ortho Evra) in continuous use for \> 30 days prior to study entry * Injection (e.g. Depo-Provera, Noristerat®) in continuous use for \> 30 days prior to study entry * Copper IUD (e.g. ParaGard) * Note: because of the decreased effectiveness of low dose progesterone-only contraceptive methods when used with retinoids, the following hormonal methods are NOT acceptable: * Low dose progesterone only oral contraceptive pill ("mini pills" e.g. Micronor®, Nor-Q.D., Ovrette) * Norplant subdermal implant * Mirena® Hormonal Implanted Uterine Device (IUD) * In addition to the above method of contraception, one of the following methods of contraception will ALSO be used for the duration of study participation and for 30 days following the last dose of study medication: * Diaphragm, cervical cap, or cervical shield with spermicide * Contraceptive sponge (e.g. Today Sponge) * Condom (male or female type) plus spermicide * Females of child-bearing potential must have a negative pregnancy test within the current menstrual cycle and within 7 days before starting drug * Participants must have the ability to understand, and the willingness to sign, a written informed consent document Exclusion Criteria: * Participants may not be taking medications that might interact with 9cUAB30; detailed list of potentially interacting medications * Participants may not be taking lipid lowering agents * Participants may not be receiving any other investigational agents * Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of retinoids * Participants with an uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with 9cUAB30, breastfeeding must be discontinued for the duration of study participation and for one month after the last dose of the study agent if the mother is treated with 9cUAB30 * Individuals known to be HIV-positive may not participate in this study; the uncertain immune status of HIV-positive people and the potential risks of taking part in this study are too great to justify this non-treatment therapy * Individuals with a history of cancer diagnosis or reoccurrence \< 5 years from study entry may not participate; however, individuals with a history of squamous or basal cell carcinoma of the skin \< 5 years from study entry will not be excluded from this study; the effects of this study agent on the immune system of people at risk for recurring cancer are unknown