Lantus Versus Humalog Mix as add-on Therapy in Type Diabetes Patients Failing Sulfonylurea and Metformin Combination Treatment

Inclusion Criteria: * Patients must have given their signed informed consent. * Males or females between 18 and 79 years of age. * Diagnosis of type 2 diabetes mellitus for at least one year. * Patients must have had continuous oral hypoglycemic treatment for at least three months using dosing of: at least half maximally labeled dose of sulfonylurea + at least 1000 mg metformin daily. * HBA1C ≥ 8 % and ≤11 %, inclusive, as measured at screening (visit 1). * Patients must have BMI of \> 25 kg/m2 at baseline * Willingness to accept, and demonstrate ability to inject insulin glargine or 75% insulin lispro protamine suspension and 25% insulin lispro injection therapy. * Ability and willingness to perform SMBG profiles using a plasma glucose meter at least twice a day. * Patients must be able to understand and willing to adhere to and be compliant with the study protocol Exclusion Criteria: * Patients, who have had stroke, MI, coronary artery bypass graft (CABG), percutaneous transluminal coronary angioplasty (PTCA) or angina pectoris within the last 12 months. * Patients with congestive heart failure requiring pharmacological treatment. * Patients on non-selective beta blockers (including ocular). * Patients with impaired renal function, as shown by but not limited to serum creatinine ≥ 1.5 mg/dl (133μmol/L) for males, or ≥ 1.4 mg/dl (124 μmol/L) for females. * Patients with acute infections. * Patients with diagnosis of dementia. * Treatment with systemic steroids or large doses of inhaled steroids. * Patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis. * Patients with planned radiological examinations requiring administration of contrasting agents. * Clinical evidence of active liver disease, or serum ALT 2.5 times the upper limit of the normal range. * Patients with history of hypoglycemia unawareness. * Pregnant or lactating females. * Failure to use adequate contraception (women of current reproductive potential only). The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.