Biodistribution and Dosimetry Evaluation of [124I]FIAU

The following are the main inclusion criteria for all subjects: 1. Males or females age \> 18 years 2. Informed consent 3. Subjects with chronic medical conditions such as hypertension and diabetes should be considered stable by the principal investigator 4. Women should be postmenopausal or surgically sterile 5. Able to return for all study assessments In addition, the following main inclusion criteria apply for subjects with suspected prosthetic joint infection: 1. Operative intervention planned in the 30 days following study enrollment 2. Prosthetic joint implant in site for more than 3 months prior to enrollment The following are the main exclusion criteria for all subjects: 1. Unable to comply with study requirements 2. Indication in the opinion of the principal investigator for surgery within 48 hours of presentation. 3. Receipt of any antibiotic therapy in the 2 weeks preceding imaging 4. Immunosuppression, e.g., human immunodeficiency virus (HIV) infection, s/p organ transplantation, receipt of steroids for \> 10 days at \> 10 mg of prednisone equivalent daily within the 90 days prior to enrollment 5. Requirement for any medication that predisposes to lactic acidosis (e.g., metformin, iron, isoniazid and salicylates; see Appendix A) 6. Requirement for any medication that has potential mitochondrial toxicity, e.g., nucleoside analogues (zidovudine, didanosine, stavudine) 7. History of an inherited mitochondrial disorder (e.g., Leber's hereditary neuropathy, neuropathy, ataxia, retinitis pigmentosa and ptosis \[NARP\], myoneurogenic gastrointestinal encephalopathy \[MNGIE\], myoclonic epilepsy with ragged red fibers \[MERFF\] and mitochondrial myopathy, encephalomyopathy, lactic acidosis and stroke-like syndrome \[MELAS\] 8. Chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection 9. Pre-existing myopathy or neuropathy 10. Abnormal liver function tests defined as alanine aminotransferase (ALT) \> the upper limit of normal (ULN), aspartate aminotransferase (AST) \> ULN, gamma glutamyl transferase (GGT) \> ULN 11. Alcohol use \> 3 units per day in men or 2 units per day in women or active intravenous drug use 12. Creatinine clearance \< 30 mL/min 13. Body mass index \> 40 14. Life expectancy \< 6 months 15. Hypersensitivity to iodine