The purpose of this study is to develop fecal tests that will determine the extent of radiation exposure in patients undergoing radiation treatment for cancer. This project will determine whether fecal biomarkers can be used to diagnose exposure to radiation.
Patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will have feces collected for use in the validation and refinement of new methods for rapid radiation biodosimetry. The stool samples will be collected before, and at defined times after TBI. Stool sampling will occur in the same manner that it does during routine patient care during HSCT.
Study Type
OBSERVATIONAL
Enrollment
2
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States
To describe changes in gene expression associated with exposure to radiation
Changes in gene expression will be measured as abundance of RNA levels relative to the weight of feces
Time frame: prior to TBI treatment (baseline) and up to 2 weeks following the last dose of TBI
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