Overuse of inhaled bronchodilator beta agonist medication results in a loss of effectiveness (i.e. tolerance). This has been shown for the short acting beta agonist salbutamol and the long acting beta agonist salmeterol. Tolerance to salmeterol is present within 24 hours. The onset of tolerance to salbutamol is not known.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
15
200mcg twice daily for a total of 7 doses
200mcg twice a day for a total of 7 doses (3.5 days).
University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Airway responsiveness as a measure of salbutamol bronchoprotection
Regular use of salbutamol results in loss of bronchoprotection. The primary outcome is to determine the onset of this tolerance.
Time frame: ten minutes post 200mcg salbutamol on day 1
Airway responsiveness as a measure of salbutamol bronchoprotection
Regular use of salbutamol results in loss of bronchoprotection. The primary outcome is to determine the onset of this tolerance.
Time frame: ten minutes post 200mcg salbutamol on day 3
Airway responsiveness as a measure of bronchoprotection. The primary outcome is to determine the onset of this tolerance.
Regular use of salbutamol results in loss of bronchoprotection. The primary outcome is to determine the onset of this tolerance.
Time frame: ten minutes post 200mcg salbutamol on day 5
Airway responsiveness as a measure of salbutamol bronchoprotection
Regular use of salbutamol results in loss of bronchoprotection. The primary outcome is to determine the onset of this tolerance.
Time frame: ten minutes post 200mcg salbutamol on day 7
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.