Organization Program of DiabEtes INsulIN ManaGement

Inclusion Criteria: * Written Informed Consent obtained before any trial-related activities Type 2 DM subjects; * Age \> 18 years old,male or female; * Continuous treated with two or more oral antidiabetic drugs (OADs) for the last 3 months,and the current HbA1c\>7.5%; * Cooperative with structured management; Exclusion Criteria: * Subjects with type 1 diabetes; * Gestational diabetes mellitus and other specific types DM; * Those who are unwilling to sign in ICF; * Subjects with repeated hypoglycemia; * Subjects with BMI\>30kg/m2; * Impaired liver function,defined as alanine aminotransferase (ALAT)\>= 2.5 or alkaline phosphatase (ALP)\>= 2 times upper referenced limit times upper normal limit; * Females of childbearing age who are pregnant, breast-feeding or have the intention of becoming pregnant or not using adequate contraceptive methods throughout the trial (adequate contraceptive measures as required by local law or practice); * Mental incapacity, unwillingness, or language barrier precluding adequate understanding or cooperation; * Any other clinically significant condition or major systemic diseases, including serious coronary heart disease, cardiovascular disease, myocardial infarction within the past 12 months; severe neurology or psychology or psychiatric diseases; serious infection; actively disseminated intravascular coagulation; * Malignant neoplastic diseases (except carcinoma in situ); * Current addiction to alcohol or other addictive substances;