Cardiopulmonary bypass (CPB) has been used successfully for cardiac surgery for over half a century. Hypothermia became a ubiquitous practice for adult patients undergoing CPB. To date, most studies have been conducted in coronary artery bypass graft (CABG) patients with conflicting results. Current evidence does not support one temperature management strategy for all patients. The purpose of this study is to compare the efficiency and safety of normothermic versus hypothermic CPB in valvular surgery patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
140
Patients will be cooled to 31-32oC (nasopharyngeal) after the beginning of CPB. Rewarming will begin 10-15 min before release of aortic cross-clamp. The gradient between heat-exchanger and nasopharynx during rewarming will be maintained at 3oC. The rewarming will be stopped at 36,5oC
State Research Institute of Circulation Patholody
Novosibirsk, Russia
Cardiac Troponin I release
Time frame: 48 hours
Need for Inotropic Support
Time frame: First 48 postoperative hours
Rate of Perioperative Myocardial Infarction
Time frame: First 48 postoperative hours
Rate of Type I and Type II neurological injury
Time frame: 7 postoperative days
Rate of Dialysis-dependent acute renal failure
Time frame: 7 postoperative days
Rate of infectious complications
Time frame: 30 postoperative days
Total units of Red Blood Cells transfused
Time frame: 7 postoperative days
Intensive Care Unit length of stay
Time frame: 30 postoperative days
Hospital length of stay
Time frame: 30 postoperative days
Rate of In-hospital mortality
Time frame: 30 postoperative days
NT-proBNP release
Time frame: First 24 postoperative hours
Bleeding from chest tubes
Time frame: First 24 postoperative hours
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