Drug Drug Interaction of BI 201335 and Tenofovir

Inclusion criteria: 1. Healthy males and female subjects and according to medical history, including the physical examination, vital signs (blood pressure, pulse rate), 12-lead electrocardiogram and clinical laboratory tests; all with acceptable findings. 2. Age =18 to =55 years 3. Weighing at least 50 kg, and body mass index \>=18.5 and BMI \<=29.9 kg/m2 (Body Mass Index). 4. Volunteers must not leave the research unit, during the entire length of the study and must be willing to comply with the protocol and complete all study-related activities. Exclusion criteria: 1. Any finding of the medical examination (including blood pressure, pulse rate and electrocardiogram) deviating from normal and of clinical relevance, as assessed by the investigator. 2. Active diseases of the gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, musculoskeletal, immunologic, rheumatologic, hormonal, neurological system, clinically relevant electrolyte disorders or bleeding disorders that require current medical treatment. 3. Diseases of the central nervous system or psychiatric disorders. 4. History of photosensitivity or recurrent rash. 5. History of orthostatic hypotension, fainting spells or blackouts. 6. Chronic or clinically relevant acute infections. 7. History of allergy/hypersensitivity (including drug allergy) which is deemed relevant. 8. Intake of drugs with a long half-life \>24:00 hours within at least one month or less than ten half lives of the respective drug before enrollment in the study (with the exception of hormonal contraceptives). 9. Use of any drugs which might influence the results of the trial up to 7 days prior to enrolment as nutraceuticals and herbal remedies that would interfere with either the absorption, distribution or metabolism of BI 201335 NA, or that prolong the QT/QTc interval. 10. Use of any investigational drug within 30 days prior to enrollment; or the planned use of any investigational drug during the course of the current study. 11. Smoking (\>10 cigarettes or \>3 cigars or \>3 pipes/day) 12. Inability to abstain from smoking more than 3 cigarettes/day during the period of dosing with study medication. 13. Drug and alcohol abuse (\>60g/day). 14. Blood donation (more than 100 mL within four weeks prior to administration or during the trial). 15. Excessive physical activities within one week prior to administration or during the trial. 16. Any laboratory value outside the reference range that is of clinical relevance at screening, according to the judgment of the investigator, and in consultation with the clinical monitor. 17. Known elevated liver enzymes in past with any compound (experimental or marketed). 18. Concomitant administration of any food product known to alter P450 enzyme activity such as grapefruit juice, Seville oranges, St. John's Wort. 19. Concomitant administration of oral contraceptives (subjects who stopped oral contraceptives at least 7 days prior to Day 1 may be included. 20. Inadequate venous access. 21. A marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTcF, or QTcB interval \>450 ms). 22. Infection with hepatitis B (HBV), or hepatitis C virus (HCV), 23. Positive test for HIV-1 or HIV-2. For women of child bearing potential (WOCBP) 24. Pregnancy or planning to become pregnant within 2 months of study completion 25. Positive pregnancy test at screening visit 26. No proof of sterilization, or not willing or unable to consistently use an acceptable method of double barrier contraception including IUD, or diaphragm with spermicidal cream/jelly and condoms for male partner, during and up to 3 months after completion/termination of the trial. 27. Lactation period with active breastfeeding from time of screening to 30 days after end of trial visit. For male subjects 28. No proof of sterilization, or not willing or unable to consistently use an acceptable method of double barrier contraception including a condom each time and female partner of child bearing potential consistently uses oral birth control pills, or an IUD, or a diaphragm with spermicidal cream/jelly). Male subjects must not father a child from administration of the first dose and up to 3 months after the last dose of study medication.