Remote Ischemic Preconditioning Before Abdominal Surgery

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Overview

Major abdominal surgeries are associated with perioperative cardiac morbidity of up to 10%. Ischemic preconditioning may have a protective effect. The purpose of this study is to find out remote ischemic conditioning by inflating a blood pressure cuff on the arm will have a protective effect.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Conditions

Perioperative/Postoperative Complications

Interventions

Remote Ischemic Pre-conditioningPROCEDURE

Cuff placed on arm. Three 5- minute cycles of blood pressure cuff inflation: cuff is inflated to 200 mm Hg for 5 minutes followed by a 5-minute deflation (reperfusion.)

ControlPROCEDURE

Cuff placed on arm uninflated for 30 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing abdominal surgery:large bowel, pancreatic and hepatic surgery Exclusion Criteria: * Chronic inflammatory disease. * Glyburide use before surgery.

Locations (1)

London Health Sciences Centre

London, Ontario, Canada

Outcomes

Primary Outcomes

Cardiovascular Events: incidence of MI, TIA/stroke, death in both groups

Time frame: One week

Secondary Outcomes

Renal function deterioration in the first week after surgery

Baseline Creatinine levels will be compared to the highest creatinine levels noted in the first 7 days of hospitalization

Time frame: One week

Data from ClinicalTrials.gov

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