CO2 absorption from the pneumoperitoneum increases over time during laparoscopic procedures. Adding 4% of oxygen to the carbon dioxide was shown in rabbits to decrease CO2 resorbtion through prevention of mesothelial hypoxia. We want to prove this concept in human and expand it to the use of full conditioning.
In order to confirm the animal data in the human, a first RCT was performed in which 20 women undergoing a laparoscopy for at least 60 minutes were randomised to a pneumoperitoneum with either 100% carbon dioxide or 96% carbon dioxide plus 4% of oxygen. Insufflation pressure and Trendelenburg were standardised at 15 mm Hg and 30° respectively. In a second trial women were randomized to either 100% carbon dioxide or 86% carbon dioxide plus 4% of oxygen + 10% nitrous oxide + humidification and set temperature of 32°C of the peritoneal cavity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
60
addition of 4% oxygen
addition of 4% oxygen + 10% nitrous oxide to the peritoneum * humidification * set temperature of 32°C
no intervention besides the use of CO2
UZ Leuven, campus Gasthuisberg
Leuven, Belgium
CO2 absorption
Measurement of end tidal CO2 during laparoscopic surgery; a decrease would improve safety (less hypercarbia)
Time frame: measurements for 60 to 240 minutes on average during surgery
hemodynamic alterations
control of other hemodynamic alterions during laparoscopic surgery.
Time frame: measurements for 60 to 240 minutes on average during surgery
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