Drug-drug Interaction Study(CKD-501, Amlodipine)

Inclusion Criteria: * Between 20 aged and 45 years old in healthy males * Body weight ≥ 55kg and 18.5 ≤ IBW \< 25 * Agreement with written informed consent Exclusion Criteria: * Subject has a history affects the ADME of drug * Hypersensitivity reactions to drugs or clinically significant hypersensitivity reactions in the history of party * Inadequate subject by medical examination(medical history, physical examination, ECG, laboratory test) * AST,ALT \> UNL \* 1.25 or Total bilirubin \> UNL \* 1.5 * Estimated GFR(MDRD) \< 80 * SBP \>150 mmHg, SBP \< 100 mmHg or DBP \> 100 mmHg, DBP \< 60 mmHg or Pulse \> 100 per/min, Pulse \< 50 per/min * Substance abuse, or a history of drug abuse showed a positive for the party * Continued to be taking caffeine (caffeine \> 5 cup/day), drinking (alcohol \> 210 g/week) or cannot stop drinking or severe heavy smoker(cigarette \> 10 cigarettes per day)during clinical trials * Medication with drug-mediated induction/inhibition metabolic enzyme within 30 days or with may affect the clinical trial * Medication within 2 weeks in the first professional medical, medicine, OTC, vitamins taking * Subject takes grapefruit within 1 month * Previously participated in other trial within 60 days * Previously donate whole blood within 60 days or component blood within 30 days * An impossible one who participates in clinical trial by investigator's decision including laboratory test result