Comparison of Adaptive Dose Painting by Numbers With Standard Radiotherapy for Head and Neck Cancer.

Inclusion Criteria: * Histologically confirmed squamous cell carcinoma of oral cavity, oropharynx, hypopharynx or larynx * Primary unresectable tumor and/or patients that refused surgery * Stages T1-4; T3-4 N0 or T(any) N1-3 for glottic cancer * Multidisciplinary decision of curative radiotherapy or radiochemotherapy * Karnofsky performance status \>= 70 % * Age \>= 18 years old * Informed consent obtained, signed and dated before specific protocol procedures Exclusion Criteria: * High risk Human Papilloma Virus (HPV) * Treatment combined with brachytherapy * Prior irradiation to the head and neck region * History of prior malignancies, except for cured non-melanoma skin cancer, curatively treated in-situ carcinoma of the cervix or other cancer curatively treated and with no evidence of disease for at least 5 years. * Distant metastases * Pregnant or lactating women * Creatinine clearance (Cockcroft-Gault) =\< 60 mL/min * Mental condition rendering the patient unable to understand the nature, scope and possible consequences of the study * Patient unlikely to comply with protocol, i.e. uncooperative attitude, inability to return for follow-up visits, and unlikely to complete the study.