Subclassification of the Syndrome of Inappropriate ADH Secretion

University of Wuerzburg50 enrolled

Overview

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH. These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hyponatremia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 years, * hyponatremia \< 132 mmol/L * SIADH Exclusion Criteria: * age \< 18 years * cerebral metastases * serum sodium \> 132mmol/L

Locations (1)

University of Wuerzburg

Würzburg, Bavaria, Germany

Data from ClinicalTrials.gov

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