Efficacy Optimizing Research of Chronic Hepatitis B Patients With Inadequate Response to NUC Therapy

Inclusion Criteria: * Male or female aged 18-65 years; * Capable of understanding and signing the informed consent. Willing to comply with the study requirements; * Serum HBsAg positive and ALT\<10ULN at study screening; * Patients have been treated with one nucleoside/nucleotide analogue for more than 6 months and are still on treatment; Exclusion Criteria: * History of viral breakthrough or genotypic resistance on previous therapy; * History of decompensated liver function, or current signs/symptoms of decompensation e.g. ascites, variceal bleeding, encephalopathy or spontaneous peritonitis; * Patient has a history of hepatocellular carcinoma(HCC) or findings suggestive of possible HCC; * Other protocol defined exclusion criteria.