The hypothesis of this study is that a radiotherapy dose of 36Gy in 12 fractions, which equates to a BED of 48.6Gy, increases the response rates of symptom relief compared to historical controls.
The hypothesis of this study is that a radiotherapy dose of 36Gy in 12 fractions, which equates to a BED of 48.6Gy, increases the response rates of symptom relief compared to historical controls. (Tey et al.) With this dose fractionation is used for bleeding, there is an increase in response rates from 55%(historical) to 75%for pain, there is an increase in response rates from 25% (historical) to 45% for obstruction, there is an increase in response rates from 25% (historical) to 45%
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
63
Palliative Radiotherapy to a total dose of 36Gy in 12 fractions
National University Hospital
Singapore, Singapore, Singapore
RECRUITINGResponse of bleeding to radiotherapy
Percentage of patients who do not require blood transfusion after radiotherapy
Time frame: At the 12th fraction of radiotherapy and at one month post radiotherapy
Number of patients who develop anorexia, nausea, vomiting as per common toxicity criteria v3.0
Toxicity
Time frame: within the first 14 days from start of radiotherapy
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