Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis

Inclusion Criteria: * Patients with Acute Liver failure as defined by AASLD.65 * Patients with Alcoholic hepatitis defined as follows: decades of heavy alcohol use (mean intake, approximately 100 g per day).The combination of an aspartate aminotransferase level that is elevated (but \<300 IU per milliliter) and a ratio of the aspartate aminotransferase level to the alanine aminotransferase level that is more than 2, a total serum bilirubin level of more than 5 mg per deciliter (86 μmol per liter), an elevated INR, and neutrophilia. Exclusion Criteria: • Known hypersensitivity to filgrastim * creatinine \> 150 µmol/L * infection or hemorrhage within the last 10 days * documented hepatocellular carcinoma * hepatitis B,C or human immunodeficiency virus seropositivity and pregnancy