Efficacy of Medical Ozone Therapy in Patients With Chronic Hepatitis B

Inclusion Criteria: 1. Male or female, not less than 16 years old； 2. HBsAg positive for over 6 months； 3. ALT over 2×ULN, TBIL less than 80µmol/L and serum HBV DNA over 10000copies/ml。 Exclusion Criteria: 1. Patient has a history of hemorrhagic or hemolysis disease; 2. Patient has any history of clinical signs/symptoms of hepatic decompensation or serious metabolic hepatic disease; 3. Patient is co-infected with HIV or HCV; 4. Patient is treated with anti-virus drug like interferon or nucleoside analogue in recent 6 months; 5. Patient is treated with immunosuppressive agent for long time, including patient has a history of organ transplantation; 6. Pregnancy; 7. Current alcohol or drug abuse; 8. Difficulty to draw blood through veins; 9. Patient has a history of carcinoma, or finding suggestive of possible hepatocellular carcinoma (HCC), or AFP over than 100ng/ml; 10. Patient has a history of any severe physical disease such as cardio-vascular, kidney events, hyperthyroidism or serious electrolyte disturbance; 11. Patient is enrolled in any other clinical trials.