Biomarkers in Samples From Young Patients With Soft Tissue Sarcoma

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research trial is studying biomarkers in samples from young patients with soft tissue sarcoma.

OBJECTIVES: * To identify the key components of driver pathways of primary and secondary soft tissue sarcomas. * To perform the next-generation sequencing on primary versus normal on undifferentiated sarcomas. OUTLINE: Genomic DNA and RNA samples from undifferentiated sarcoma tumors are analyzed by next-generation sequencing for somatic mutations. Normal matched lymphocytes and tissue are also analyzed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcoma

Interventions

DNA analysisGENETIC

RNA analysisGENETIC

mutation analysisGENETIC

nucleic acid sequencingGENETIC

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Banked childhood samples from the COG-D9902 soft tissue sarcoma biology and banking study * Rhabdomyosarcoma, NOS PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Occurrence of somatic mutations in driver genes and mutations in other genes that occur individually

Data from ClinicalTrials.gov

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