Objective: Insulin resistance during normal pregnancy and in gestational diabetes mellitus (GDM) are unknown. New criteria are based on fasting glucose levels since the beginning of pregnancy. Inositol, a putative second messenger of insulin, correlates with the degree of insulin resistance. Dietary supplementation of inositol improves insulin resistance in patients with GDM.
Methods: A randomized double-blind study was carried out in women with GDM. Patients were randomly exposed to inositol and placebo. Increase of BMI, blood glucose at 75 grams oral glucose tolerance test (OGTT), fetal and neonatal adverse outcome, and insulin treatment were correlated to inositol exposure.
Study Type
OBSERVATIONAL
Enrollment
30
inositol exposure in early GDM
University of Chieti
Chieti, CH, Italy
Insulin therapy in early diagnosis of GDM
Inositol supplementation and diet with/without insulin therapy in early GDM
Time frame: 6 months
altered OGTT
OGTT altered at 24-28 wks in inositol and control group
Time frame: 6 months
delivery and neonatal outcomes
prevention of maternal and fetal adverse outcomes deriving from GDM (LGA fetuses, poly-hydramnios, C-section rate, gestational age at delivery, birthweight, birth injuries)
Time frame: 6 months
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