Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors

N/AActive Not RecruitingNCT01343342

Laval University200 enrolled

Overview

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors. To do so, the metabolic risk factor response to an n-e PUFA supplementation will be compared in carriers and non-carriers of polymorphism within genes acting as fatty acids sensors.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

200

Conditions

Cardiovascular Disease

Interventions

n-3 PUFA supplementationDIETARY_SUPPLEMENT

3g per day of n-3 PUFA supplementation (1.9g EPA, 1.1g DHA). 5 capsules per day (1g fish oil each, 5g of fish oil/day)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy men and women aged between 18 to 50 years; * having a BMI between 25 and 40kg/m2; * plasma triglycerides levels \<4.0 mmol/L; * non-smokers; * free of any thyroid or metabolic disorders requiring treatment such as diabetes, hypertension, severe dyslipidemia, and coronary heart disease. Exclusion Criteria: * subjects taking medication for hyperlipidemia, hypertension, diabetes or taking anticoagulant or n-3 PUFA supplementation; * having a taste aversion for fish, fish allergy or regular alcohol drinker; * body mass index \> 40kg/m2; * pregnant or nursing women.

Locations (1)

Institute of Nutraceutical and Functional Foods (INAF), Laval University

Québec, Canada