Autism is one of those disorders in Autism spectrum disorders (ASD), which characterized by social interaction abnormalities, impaired verbal and non-verbal communication, and repetitive, obsessive behavior, while the therapeutic effect of current treatments remains limited progress .Neural hypoperfusion and immune deregulation are the two key pathologies associated with Autism. Human umbilical cord mesenchymal stem cells (hUC-MSCs) and human cord blood mononuclear cells (hCB-MNCs) have been shown to have the ability to modulate the immune response and enhance angiogenesis, suggesting the novel and promising therapeutic strategy. In this study, the safety and efficacy of hUC-MSCs and hCB-MNCs transplantation will be evaluated in patients with Autism.
To investigate the safety and efficacy of human cord blood mononuclear cells and human umbilical cord mesenchymal stem cells transplantation in patients of Autism.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
37
Participants will be given rehabilitation therapy plus hCB-MNCs transplantation.
Participants will be given rehabilitation therapy plus and hCB-MNCs and hUC-MSCs transplantation.
Shandong Jiaotong Hospital
Jinan, Shandong, China
Childhood Autism Rating Scale,CARS
Time frame: 6 months after treatment
Clinical Global Impression Scale,CGI
Time frame: 6 months after treatment
Aberrant Behavior Checklist,ABC
Time frame: 6 months after treatment
Adverse Event and Serious Adverse Event
Time frame: 6 months after treatment
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