Single Rising Dose Study to Assess Safety, Tolerability and Pharmacokinetics of BI 661051.

Inclusion criteria: 1. Healthy males based upon a complete medical history, including the physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead electrocardiogram (ECG), clinical laboratory tests. There is no finding deviating from normal and of clinical relevance. There is no evidence of a clinically relevant concomitant disease. 2. Age =18 and age =50 years. 3. BMI =18.5 and BMI =30 kg/m2 (Body Mass Index). 4. Signed and dated written informed consent prior to admission to the study in accordance with Good Clinical Practice (GCP) and the local legislation. Exclusion criteria: 1. Any finding of the medical examination (including BP, PR and ECG) deviating from normal and of clinical relevance. 2. Any evidence of a clinically relevant concomitant disease. 3. Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders. 4. Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders. 5. History of relevant orthostatic hypotension, fainting spells or blackouts. 6. Chronic or relevant acute infections. 7. History of relevant allergy/hypersensitivity (including allergy to drug or its excipients) as judged clinically relevant by the investigator. 8. Intake of drugs with a long half-life (\>24 h) within at least 1 month or less than 10 half-lives of the respective drug prior to administration. 9. Use of drugs which might reasonably influence the results of the trial based on the knowledge at the time of protocol preparation within 10 days prior to randomisation. 10. Participation in another trial with an investigational drug within 30 days prior to randomisation. 11. Smoker (\>10 cigarettes or \>3 cigars or \>3 pipes/day). 12. Inability to refrain from smoking on trial days as judged by the investigator. 13. Alcohol abuse (more than 30 g/day). 14. Drug abuse. 15. Blood donation (more than 100 mL within 4 weeks prior to randomisation or during the trial). 16. Excessive physical activities (within 1 week prior to randomisation or during the trial). 17. Any laboratory value outside the reference range that is of clinical relevance. 18. Inability to comply with dietary regimen of the study centre.