The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

Jinhua Central Hospital46 enrolled

Overview

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critically Ill

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * critically ill patients who required hemodynamic monitoring using PiCCO Exclusion Criteria: * patients with renal dysfunction * those older than 80 years * pregnant women

Locations (1)

Jinhua central hospital

Jinhua, Zhejiang, China

Outcomes

Primary Outcomes

global end diastolic volume

this is measured by transpulmonary thermodilution technique

Time frame: within 12 h after measurement of BNP

Data from ClinicalTrials.gov

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