Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Inclusion criteria: * scheduled for screening colonoscopy * off NSAID or aspirin therapy in accordance with OHSU endoscopy clinic guidelines * INR 0.90-1.20 * hemoglobin ≥ 13.5 (men) or 12.0 (women) * platelets ≥100,000/μL * Chem screen results within normal limits * negative (serum or urine) pregnancy test done ≤7 days prior to colonoscopy for women of childbearing potential only * ASA performance status \<2 Exclusion criteria: * history of colon cancer or adenomatous polyps * current smoker * medical history of chronic obstructive pulmonary disease * current oral steroid therapy * current therapy with valproate or other pharmacological drugs associated with HDAC inhibition * use of oral antibiotics within 3 months prior to entry into study * significant active medical illness which in the opinion of the investigator would preclude collection/interpretation of colon tissue * diagnosis of hemophilia, van Willebrand's disease or other bleeding disorder * use of warfarin or other blood thinning agents * inflammatory bowel disease.