Full conditioning of the peritoneal cavity during laparoscopic surgery will decrease post-operative pain, inflammation and adhesion formation. Full conditioning will decrease an inflammatory response of the peritoneum and decrease pain and adhesion formation.
Randomized controlled trial (RCT) comparing carbon dioxide to full conditioning (addition of oxygen, nitrous oxide, humidification and temperature control, dexamethasone and Hyalobarrier gel) Women undergoing laparoscopy for endometriosis, myomectomy or adhesiolysis will be randomized to either group and will be compared for pain (VAS scores); inflammation (White blood cells, CRP) and adhesions scored by second look laparoscopy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
22
addition of 4% oxygen + 10% nitrous oxide to the pneumoperitoneum + humidification + temperature regulation at 32°C
100% carbon dioxide used for the pneumoperitoenum
UZ Leuven
Leuven, Belgium
adhesion formation after laparoscopic surgery
second look laparoscopy to assess adhesions formed after initial surgery
Time frame: 2 weeks after primary surgery
Post-operative pain
pain assessed by VAS scores
Time frame: recorded until 3 days after surgery
inflammation
bloodsamples to test for C reactive protein and white blood cells
Time frame: recorded until 3 days after surgery
time to first flatus and stool
patients will be asked when first flatus and first stool appeared. (measured as hours after surgery)
Time frame: recorded until 3 days after surgery
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