Safety and Tolerability of Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Advanced Dry Age Related Macular Degeneration

Inclusion Criteria: * Adult male or female over 55 years of age. * Patient should be in sufficiently good health to reasonably expect survival for at least four years after treatment * Clinical findings consistent with advanced dry AMD with evidence of one or more areas of \>250microns of geographic atrophy (as defined in the Age-Related eye Disease Study \[AREDS\] study) involving the central fovea. * GA defined as attenuation or loss of RPE as observed by biomicroscopy, OCT, and FA. * No evidence of current or prior choroidal neovascularization in the treated eye * The visual acuity of the eye to receive the transplant will be no better than 20/400. The visual acuity of the eye in the better vision cohort to receive the transplant will be no better than 20/100. * The visual acuity of the eye that is not to receive the transplant will be no better than 20/400 for the worse vision patients and no worse than 20/100 for the better vision patients. * Electrophysiological findings consistent with advanced dry AMD. * Medically suitable to undergo vitrectomy and subretinal injection. * Medically suitable for general anesthesia or waking sedation, if needed. * Medically suitable for transplantation of an embryonic stem cell line: Any laboratory value which falls slightly outside of the normal range will be reviewed by the Medical Monitor and Investigators to determine its clinical significance. If it is determined not to be clinically significant, the patient may be enrolled into the study. * Normal serum chemistry (sequential multi-channel analyzer 20 \[SMA-20\]) and hematology (complete blood count \[CBC\], prothrombin time \[PT\], and activated partial thromboplastin time \[aPTT\]) screening tests. (NOTE:With the exception of abnormalities specifically identified in the exclusion criteria) * Negative urine screen for drugs of abuse. * Negative human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV) serologies. * No history of malignancy (with the exception of successfully treated (excised) basal cell carcinoma\[skin cancer\] or successfully treated squamous cell carcinoma of the skin). * Negative cancer screening within previous 6 months: * complete history \& physical examination; * dermatological screening exam for malignant lesions; * negative fecal occult blood test \& negative colonoscopy within previous 7 years; * negative chest roentgenogram (CXR); * normal CBC \& manual differential; * negative urinalysis (U/A); * normal thyroid exam; * if male, normal testicular examination; digital rectal examination (DRE) and prostate specific antigen (PSA); * if female, normal pelvic examination with Papanicolaou smear; and * If female, normal clinical breast exam and, negative mammogram. * If female and of childbearing potential, willing to use two effective forms of birth control during the study. * If male, willing to use barrier and spermicidal contraception during the study. * Willing to defer all future blood, blood component or tissue donation. * Able to understand and willing to sign the informed consent Exclusion Criteria: * Presence of active or inactive CNV in the eye to be treated. * Presence or history of retinal dystrophy, retinitis pigmentosa, chorioretinitis, central serious choroidopathy, diabetic retinopathy or other retinal vascular or degenerative disease other than ARMD. * History of optic neuropathy. * Macular atrophy due to causes other than AMD. * Presence of glaucomatous optic neuropathy in the study eye, uncontrolled IOP, or use of two or more agents to control IOP (acetazolamide, beta blocker, alpha-1-agonist, antiprostaglandins, anhydrous carbonic inhibitors). * Cataract of sufficient severity likely to necessitate surgical extraction within 1 year. * History of retinal detachment repair in the study eye. * Axial myopia of greater than -8 diopters * Axial length greater than 28 mm. * History of malignancy (with the exception of successfully treated \[excised\] basal cell carcinoma\[skin cancer\] or successfully treated squamous cell carcinoma of the skin). * History of myocardial infarction in previous 12 months. * History of diabetes mellitus. * History of cognitive impairments or dementia which may impact the patients ability participate in the informed consent process and to appropriately complete evaluations. * Any immunodeficiency. * Any current immunosuppressive therapy other than intermittent or low dose corticosteroids. * Alanine transaminase/aspartate aminotransferase (ALT/AST) \>1.5 times the upper limit of normal or any known liver disease. * Renal insufficiency, as defined by creatine level \>1.3 mg/dL. * A hemoglobin concentration of less than 10 gm/dL, a platelet count of less than 100k/mm3 or an absolute neutrophil count of less than 1000/mm3 at study entry. * Serologic evidence of infection with Hepatitis B, Hepatitis C, or HIV. * Current participation in any other clinical trial. * Participation within previous 6 months in any clinical trial of a drug by ocular or systemic administration. * Any other sight-threatening ocular disease. * Any history of retinal vascular disease (compromised blood-retinal barrier. * Glaucoma. * Uveitis or other intraocular inflammatory disease. * Significant lens opacities or other media opacity. * Ocular lens removal within previous 3 months. * Ocular surgery in the study eye in the previous 3 months * If female, pregnancy or lactation. * Any other medical condition, which, in the Investigator's judgment, will interfere with the patient's ability to comply with the protocol, compromises patient safety, or interferes with the interpretation of the study results.