Study Comparing Radiation Therapy and Chemotherapy With or Without Nimotuzumab

Inclusion Criteria * Aged 18 to 75 years old; * Histological or cytological confirmation of SCC in oral cavity, oropharynx, hypopharynx, or larynx; * Stages III or IV disease * Unresectability according to responsible surgeon or medical staff's opinion; * Performance status 0 or 1 * Present indication for radiation therapy and chemotherapy treatment with cisplatin; * Adequate hepatic, renal and medullar functions, indicated by: * Life expectancy above 6 months. Exclusion Criteria * Presence of nasopharyngeal, paranasal sinuses, or salivary glands carcinoma; * Presence of known distant metastasis; * Presence of any other active neoplasm or history of any tumor diagnosed in the last 5 years * Patients with inability to eat normally, in whom a gastric or enteral tubing was not possible at least 2 weeks before their enrollment in the study; * Previous treatment with chemotherapy, radiation therapy, or EGFR inhibitors of any pharmacological class; * Presence of serious comorbidity that, in the investigator's opinion, will put the patient at risk or will jeopardize protocol compliance; * Active known seropositivity for HIV, hepatitis B or C * Presence of a significant neurological or psychiatric disease, as per the investigator's judgment; * Hypersensitivity or allergy to any of the study treatments; * Presence of uncontrolled hypercalcemia; * Pregnancy or breastfeeding; * Female patients of childbearing potential who wish to become pregnant or are unwilling, as well as their partners, to use an appropriate contraceptive method throughout the study period; * Participation in any clinical trial in the last 12 months.