The primary purpose of the investigation is to identify differences in embryo development after follicle stimulation with two different gonadotrophins.
So far the assessment of the development potential of the single embryo has been limited by the vulnerability of the embryos when exposed to fluctuations in temperature and CO2 levels. Thus embryos can only be allowed to leave incubators for a very limited time period. However, with the development of time-lapse systems for clinical use it is possible to make continuous time-lapse recordings of embryos while they are in a safe incubator environment. The embryos are not compromised, but the entire embryonic development can still be seen, and will subsequently provide new and essential information on the competence of the single embryo. Based on the above it is expected that the probability of selecting the most viable and competent embryo is increased, which, in turn, will increase the success rate for couples seeking infertility treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
291
100 - 300 IU for stimulation of women in ART treatment
100 -300 IU for stimulation of women in ART treatment
The fertility clinic
Brædstrup, Denmark
Number of Top Quality Embryos day 2
The oocytes are inseminated and loaded to the time-lapse instrument and cultured for two days. The embryo developemnt are followed at the movie and the embryos are scored according to a standard scoring criteria at 44 h after insemination
Time frame: 44 h after insemination
Implantation rate
The pregnancy is verified by a blood sample two weeks after embryo transfer and the number of embryos implanted are verified by ultrasound scanning five weeks after embryo transfer.
Time frame: 5 weeks after embryo transfer
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