Preventing Urinary Tract Infection Post-Surgery

Betsy Foxman200 enrolled

Overview

Approximately 10-27% of patients undergoing gynecologic surgeries develop a catheter associated urinary tract infection (CAUTI) in the post operatory period, as bladder catheterization is a common practice in gynecologic surgery. Cranberry products provide alternative means for preventing CAUTI and could result in decreased use of antimicrobials. In this pilot study we will enroll 200 women post gynecologic surgery and randomize them to take either cranberry powder capsules or placebo powder capsules. The low risk of harm associated with using cranberry to reduce UTI coupled with its potential benefit makes it a desirable intervention for the prevention of CAUTI. The conduct/ results of this pilot /feasibility study will prepare us for the conduct of a large scale clinical trial.

Cranberry products prevent bacteria that cause UTI, especially Escherichia coli, from adhering to bladder cell wall thus preventing infection. Adherence of type 1 pili is inhibited by the fructose and of p pili by the proanthocyanidins present in cranberry.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

200

Conditions

Urinary Tract Infection

Interventions

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Presenting at the gynecology clinic for a pre-operatory visit 2. Ability to give informed consent 3. Willing to take cranberry capsules for up to 6 weeks 4. 18 of age or older Exclusion Criteria: 1. Pregnancy 2. History of nephrolithiasis 3. History of allergy to cranberry 4. Patient on anticoagulant medicine to be re-started during the 4-6 weeks after surgery 5. Less than 18 years old

Outcomes

Primary Outcomes

Participants With Clinically-diagnosed and Treated UTI's.

The primary endpoint was the number of participants who were clinically-diagnosed and treated for UTI whether or not results from a urine culture were available. All UTI's were confirmed via medical records.

Time frame: From surgery to post-op visit, approximately 6 weeks post surgery