a 3.0T Magnetic Resonance Imaging Study

Huazhong University of Science and Technology200 enrolled

Overview

Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Primary Open Angle Glaucoma

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of \>0.2) * matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry ) Exclusion Criteria: * optic neuropathy * neurological disorder * other diseases and use of systemic medications which affect optic nerve or the visual ﬁeld underwent complete eye examination and visual-field testing.

Data from ClinicalTrials.gov

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